However, hα-Syn+/Nrf2-/- mice spent significantly less time exploring the central field than the hα-Syn+/Nrf2+/+ mice (Fig. 2K, Supplementary Table 1; P = 0.0002, F3, 60 = 8.647, One-way ANOVA) signifying greater anxiety-like behavior in the novel environment (unprotected central area of the field) in these animals. The gene discussed is NFE2L2; the disease is Anxiety.