Familial hypercholesterolemia (FH), the most frequent autosomal dominant disease, is caused by mutations in the LDL receptor (LDLR), Apo lipoprotein B (Apo B), or less frequently proprotein convertase Subtilisin/Kexin type 9 (PCSK9) genes [1]. The gene discussed is PCSK9; the disease is familial hypercholesterolemia.