Tumor cells escape through a variety of mechanisms, including low expression of tumor surface antigens, making it difficult for the immune system to monitor them; the secretion of immunosuppressive factors (such as transforming growth factor beta, interleukin-10) and different regulation and induction of sexual lymphocytes or myeloid cells (such as regulatory T cells, bone marrow-derived suppressor cells); and downregulation or complete loss of HLA-I antigen expression to avoid the recognition and killing of cytotoxic T cells [42]. The gene discussed is IL10; the disease is neoplasm.