Then, whether miR-221-3p can be used as a ceRNA that interacts with Linc00472 in ccRCC to change the expression level of VEGFR2 by upregulating C3aR1, thereby regulating the growth and metastasis of ccRCC through the HIF pathway, needs further verification. This evidence concerns the gene C3AR1 and nonpapillary renal cell carcinoma.