In this study, miR-17-5p may affect the proliferation, migration, and invasion of ccRCC cells by upregulating the expression of HLA-DQA1 and HLA-DQB1; on the other hand, it may increase the expression of C3aR1 and C5aR1 in the classical HIF pathway. This evidence concerns the gene C5AR1 and nonpapillary renal cell carcinoma.