Indeed, Berulava et al. investigated the role of the m6A demethylase FTO in heart failure in a cardiac-specific Fto knockout (Fto-cKO) mouse model and observed a more severe reduction in the ejection fraction and a higher degree of dilatation in Fto-cKO mice subjected to TAC surgery [63] (Figure 2(c) and Table 1). The gene discussed is FTO; the disease is heart failure.