METTL3 and cardiac hypertrophy: Unlike global Mettl3 knockout, Fto knockout mice (Fto−/−) is not embryonically lethal; however, compared to their wild-type counterparts, Fto−/− mice are characterized by growth retardation, increased heart rates, altered ventricular repolarization, enhanced vulnerability to stress-induced tachyarrhythmias, and cardiac hypertrophy [65].