Silencing of YTHDF2 in human HCC cells or ablation of Ythdf2 in mouse hepatocytes was found to aggravate inflammation, vascular reconstruction, and metastatic progression via decay of m6A-containing interleukin 11 and serpin family E member 2 (SERPINE2) mRNAs (Table 1). This evidence concerns the gene SERPINE2 and hepatocellular carcinoma.