METTL3 and aortic aneurysm: Therefore, conducting more in-depth research to determine the function and mechanisms of METTL3 in the cardiovascular system by using mice with cell-specific Cre- (such as Nkx2-5-Cre, cTNT-cre, and Mef2c-AHF-cre) mediated Mettl3 knockout under the same stimulation conditions or to identify its effects on other cardiovascular diseases (e.g., diabetic cardiomyopathy, aortic aneurysm/dissection, atherosclerosis, and pulmonary arterial hypertension) is warranted.