In conjunction, the complex was able to alter p53 expressions to interfere with apoptosis in breast carcinoma, induced by the intrinsic apoptotic pathway facilitated by Bcl2 and Bax and associated with MMP9-regulated tumor pathways at the same time regulating the PI3K/Akt/mTOR/VEGF pathway. The gene discussed is AKT1; the disease is breast carcinoma.