The latter forms of HAE are due to mutations in the F12 gene (HAE-FXII), the angiopoietin-1 gene (HAE-ANGPTI), the plasminogen gene (HAE-PLG), the kininogen1 gene (KNG1), the myoferlin gene (HAE-MYOF), or as of yet unknown mutations (HAE-UNK). Here, PLG is linked to hereditary angioedema.