As a conclusion, there are distinctive features between bradykinin-mediated and mast-cell mediated angioedema, ie, patients with BMAE have younger age and longer disease and attack duration, a higher frequency of positive family history, hand–feet involvement and upper airway edema, and the burden of disease seems to be higher in the BMAE group as compared to the MMAE group, even though the activity of the disease and days with angioedema are lower in the BMAE group. Here, KNG1 is linked to angioedema.