In the early DN patients included in the study, urine microalbumin, urine microalbumin/urinary creatinine, 24 h urine protein quantification, creatinine, and cystatin-C were all higher than those of diabetic patients, but the eGFR was reduced, and they were statistically significant (p < 0.05). This evidence concerns the gene CST3 and liver dysplastic nodule.