METTL3 and hepatocellular carcinoma: Univariate analysis showed that higher expression of YTHDF1, WTAP, HNRNPC, RBM15, METTL3, KIAA1429, YTHDC1, and YTHDF2 and lower expression of ZC3H13 were statistically related to poorer OS of HCC patients (all P < 0.05, supplementary figure 1A); multivariate analysis showed that the expression of YTHDF1, WTAP, HNRNPC, RBM15, METTL3, KIAA1429, and YTHDF2 still remained significantly related with OS after adjusting for gender, age, histologic grade, T stage, N stage, M stage, and TNM stage (all P < 0.05, supplementary figure 1B-1J).