CHAT and type 1 diabetes mellitus: Yang et al. [37] established a T1DM mouse model and found that the gastric ChAT level was reduced significantly, the myenteric cholinergic neurons and their fibers decreased significantly, and the numbers of cholinergic neurons in the gastric myenteric plexus and smooth muscle decreased from the 4th week of DM, which aggravated the progress of DGP.