The expression of TGF-β1 and CTGF in myocardial infarction model rats showed that TGF-β1 was mainly expressed in the onset of myocardial infarction, acute inflammatory response, and postrepair stage of myocardial infraction, while CTGF played a role in the development stage of myocardial fibrosis [36]. This evidence concerns the gene CCN2 and Myocardial fibrosis.