TNF and type 2 diabetes mellitus: The studies in [20–23] have shown that there is obvious high expression of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and other inflammatory factor-related genes in TCM heat syndrome, and more and more studies [24–26] suggest that T2D may be an inflammatory response mediated by cytokines and is an immune disease.