Furthermore, the codominant model showed that the GJA1 rs2071165 AA genotype had a significant association with an increased risk of GC in women with tumor stage III/IV (OR = 4.19, 95% CI = 1.41–12.45, p=0.01) and the rs2071165 AA and AG genotypes were significantly associated with an increased risk of GC in women with negative recurrence/metastasis (OR = 2.84, 95% CI = 1.03–7.80, p=0.03; OR = 1.82, 95% CI = 1.06–3.10, p=0.03, respectively). The gene discussed is GJA1; the disease is gastric cancer.