According to web-based SNP selection tools (https://manticore.niehs.nih.gov/snpinfo/snpfunc.html), two functional SNPs were selected in the GJA1 rs2071165 gene region for further analysis in our study.rs2071165is located in the upstream-variant-2KB region ofGJA1 and is predicted to be a transcription factor binding site, which may influence the expression of Cx43 in GC patients. The gene discussed is GJA1; the disease is gastric cancer.