A top candidate for a functionally relevant association with T1D is EHMT2 that has been shown to regulate T cell development and differentiation (Scheer and Zaph, 2017) in its function as methyltransferase that di-methylates lysine 9 of histone 3 (H3K9), a signal for transcriptional repression. Here, EHMT2 is linked to type 1 diabetes mellitus.