For example, the rs5918 variant, located in the ITGB3 gene (chr17:45360730), reduces the efficacy of aspirin and clopidogrel (Dropinski et al., 2007; Motovska et al., 2009) (indicated for coronary artery disease and myocardial infarction) and it shows a higher allele frequency in IBS and TSI than in Roma (Supplementary Table 11). Here, ITGB3 is linked to irritable bowel syndrome.