Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1/CD39) is not the only ATP-degrading enzyme that is expressed by tumor cells; for example, nucleoside triphosphatase, cancer-related (NTPCR) is also expressed by some tumors which can bind to extracellular ATP and then convert it to adenosine (Moesta et al., 2020). This evidence concerns the gene ENTPD1 and neoplasm.