DeWaal et al. (2018) demonstrated that deficiency in HKII inhibited glycolysis metabolism of hepatocellular carcinoma and promoted OXPHOS and chemotherapy-sensitivity of hepatocellular carcinoma. A large number of experiments have confirmed that serum HKII is helpful for the detection and prognosis of PCA (Mao et al., 2018). This evidence concerns the gene HK2 and hepatocellular carcinoma.