Another example showed KDM1A can demethylate K185 of transcription factor E2F1 which has an important role in regulating the cell cycle and tumor suppressor genes in lung cancer cells (Huang et al., 2007; Wang et al., 2009; Kontaki and Talianidis, 2010; Xie et al., 2011). This evidence concerns the gene KDM1A and neoplasm.