MEG3 inhibits cancer progression through several independent mechanisms, including regulation of the tumor suppressor genes p53 and Rb (Li et al., 2016; Lyu et al., 2017), inhibition of angiogenesis (Gordon et al., 2010), acting as a competitive endogenous (ce)RNA (Qin et al., 2017; Zhang et al., 2017; Zhang and Guo, 2019; Gong and Huang, 2020), and induction of EMT and invasion via autophagy (Gong and Huang, 2017; Yang et al., 2020). The gene discussed is RB1; the disease is cancer.