MEG3 and glioblastoma: By analyzing GSCALite database, we found that the heterozygous deletion of MEG3 occurred in 27.73 and 20.08% of GBM and LGG, respectively (Figures 2A,C), and Pearson correlation analysis showed that mRNA expression of MEG3 was significantly positively correlated with its CNV in both GBM (r = 0.32, P < 0.05) and LGG group (r = 0.16, P < 0.05) (Figure 2B), which indicated that mRNA expression of MEG3 was significantly affected by CNV.