PRDM13 and North Carolina macular dystrophy: Indeed, disruption of non-coding topologically associated domains have been associated with limb malformations (Lupiáñez et al., 2015; Spielmann et al., 2018), and non-coding variants upstream of PRDM13 and CCNC have been linked to North Carolina macular dystrophy (Small et al., 2016; Green et al., 2021).