In fact, ctrp1, a C1q/TNF-related adipokine strongly implicated in pathogenesis of non-alcoholic fatty liver disease (NAFLD), a human chronic liver disease associated with several metabolic-related disorders including insulin resistance (diabetes) and inflammation (Shabani et al., 2017), was one of the most significantly downregulated genes both in the liver and in the muscle of sick animals. The gene discussed is C1QTNF1; the disease is metabolic dysfunction-associated steatotic liver disease.