ABCC1 and hemochromatosis type 1: ABCC1 has an important role in maintaining cellular redox status (Cole, 2014) also in placental cells (Granitzer et al., 2020), GCLM is the rate-limiting enzyme in the synthesis of the major cellular anti-oxidant GSH (Liu, 2013), and HFE malfunction is associated with systemic iron overload (hemochromatosis) promoting oxidative stress (De Souza et al., 2015).