The T allele at rs12203592, a variant in intron 4 of Interferon Regulatory Factor 4 (IRF4), conferred increased risk of de novo abnormal cytogenetic AML, de novo normal cytogenetic AML, MDS and t-MDS (OR = 1.38; 95% CI, 1.26–1.51, Pmeta = 2.8 × 10–12). The gene discussed is IRF4; the disease is acute myeloid leukemia.