Increased expression of AKT Serine/Threonine Kinase 1, AKT1 at 14q32.33 was associated with risk for the development of de novo AML and MDS (OR = 1.56; 95% CI, 1.25–1.95, Pmeta = 1.0 × 10–4) (Figure 4). The gene discussed is AKT1; the disease is acute myeloid leukemia.