Furthermore, analyses of multiple B-cell malignancies recently identified a rs9392017, adjacent to IRF4, as a pleiotropic susceptibility variant associated with both CLL and HL (Di Bernardo et al., 2008; Mifsud et al., 2015; Schofield et al., 2016; Law et al., 2017). The gene discussed is IRF4; the disease is B-cell chronic lymphocytic leukemia.