IRF4 and acute myeloid leukemia: ASSET analyses also identified another variant in modest linkage disequilibrium (LD), r2 = 0.7, with rs12203592 in the regulatory region of IRF4; the A allele at rs62389423, showed a putative association with de novo AML and MDS (OR = 1.36; 95% CI, 1.21-1.52, Pmeta = 1.2 × 10–7) (Figure 2A).