NFKB1 and cancer: In addition to the aforementioned pathways, NLRC5 is involved in the regulation of the TLR4/MyD88/NF-κB, JAK2/STAT3, and TGF-β1/Smad signaling pathways, and plays a role in hepatic fibrosis, malignant tumors, ethanol-induced hepatic injury and other diseases, as shown in Table 2.