SCAMP1 can increase LIM homeobox transcription factor 1 alpha (LMX1A) levels by negatively regulating miR-499a-5p expression, following LMX1A-mediated transcriptional activation of NLRC5, and can promote malignant biological behavior of glioma cells by attenuating the activity of the Wnt/β-catenin signaling pathway (13). The gene discussed is LMX1A; the disease is central nervous system cancer.