However, in recent years, studies have found that NLRC5 is also associated with CNS infection (CNSI) (6–9), neuronal development (10), and neuropsychiatric disorders, such as cerebral ischemia/reperfusion (I/R) injury (11, 12), glioma (13–15), multiple sclerosis (MS) (16), epilepsy (17), schizophrenia (SCZ), and bipolar disorder (BD) (18, 19). Here, NLRC5 is linked to brain ischemia.