In this study, we found that the RPL22 expression in the skin lesions of psoriasis patients and IMQ-induced psoriasis-like mouse models well as psoriasis-like HaCaT cells was significantly increased, and RPL22 could also promote keratinocytes proliferation, inhibit keratinocytes apoptosis and induce inflammatory cell chemotaxis in vitro, further aggravate the progression of psoriasis. Here, RPL22 is linked to psoriasis.