Similarly, our studies also detected the expression of psoriasis-associated cytokines such as IL-1β, IL-23, TNF-α and IL-17a by RT-qPCR and found the levels of IL-1β, IL-23 and IL-17a were significantly increased while TNF-α showed no change in RPL22-overexpressed KCs, which was in accordance with RPL22 knockdown (Figure 5D). The gene discussed is TNF; the disease is psoriasis.