In summary, our study revealed that hyperacetylation of histone H3K27 in the promoter region of RPL22 in the skin lesions of psoriasis patients induced RPL22 overexpression, upregulated RPL22 controlled the cell cycle by up-regulating the expression of cyclinD1 to promote the keratinocytes proliferation and enhanced the chemotaxis of CD4+ T cells by up-regulating CXCL10 expression in KCs to induce inflammatory reaction to participate in the occurrence and development of psoriasis (Figure 8). This evidence concerns the gene CXCL10 and psoriasis.