DSG3 and acquired polycythemia vera: High quality data from a prospective, multicenter, open-label, randomized trial of continued rituximab administration in PV demonstrated complete and sustained remission at the end of the second year of follow-up in 89% of 46 patients who received rituximab; rapid normalization of anti-desmoglein-3 (DSG-3) antibody titers post B cell depletion was also shown, thereby underscoring the short-lived nature of ASCs producing anti-DSG-3 autoantibodies (314, 315).