However, although not statistically significant (OR=0.76, 95% CI=0.54-1.05, p=9.67×10-2 for response; HR=1.09, 95% CI=0.93-1.27, p=3.06×10-1 for OS), a higher number of infiltrated CD8+ T cells in ccRCC was associated with poor prognosis, which is in line with the findings of previous studies (37, 42). The gene discussed is CD8A; the disease is nonpapillary renal cell carcinoma.