An increased number of findings supports the role of innate immunity in RA; indeed, many innate immune mechanisms are responsible for the production of a significant proportion of cytokine and chemokine synthesis involved in RA pathogenesis, such as Tumor Necrosis Factor α (TNFα), interleukin (IL)-6, and IL-1 (5, 6). The gene discussed is IL1B; the disease is rheumatoid arthritis.