Excessive lymphocytic infiltrates (8), heightened rates of IL-18–expressing cells (9), and tissue macrophages (10), elevated transcript levels of both interferon-γ (IFNγ) (11–13), and inflammasome molecules (14) in minor salivary gland (MSG) tissues, as well high serum levels of IL-18 and apoptosis-associated speck-like protein (ASC) (14, 15), have been all designated as key findings in SS patients at high risk for lymphoma development. This evidence concerns the gene IL18 and synovial sarcoma.