Of note, in human and murine colon cancer cell lines, silencing of the gene expressing Lp-PLA2 (PLA2G7) led to reduction of tumor size by 42% in vivo and the PLA2G7 knockout Apc Min/+ mice displayed vigorous suppression of intestinal polyposis and colon tumor formation (37). Here, APC is linked to malignant colon neoplasm.