Toward the same direction, several gene variants implicated in central inflammatory and IFN/B cell activation pathways, such as tumor necrosis factor alpha-induced protein 3 (TNFAIP3) variant (16, 17), three prime repair exonuclease 1 (TREX-1) (18), B-cell activating factor (BAFF) (19), and BAFF-R (20) have been shown to increase susceptibility for SS-related lymphoma. The gene discussed is TREX1; the disease is lymphoma.