CD4 and type 1 diabetes mellitus: Although the number of antigens reported to be recognized by insulitic CD4+ and CD8+ T cells from donors with T1D is limited, CD8+ epitopes from native and neoepitopes from islet-derived proteins have been identified (25, 26, 39) along with broad CD4+ T cell reactivity (28–30); see (40) for a review of islet proteins with native and neoantigen epitope targets.