To verify the expression of heparanase in chronic gastritis, we obtained gastroscopy biopsy specimens of fresh gastric mucosal tissues from patients who underwent electronic gastroscope for gastritis-related symptoms, including H. pylori-positive chronic gastritis mucosal tissues, H. pylori-positive chronic atrophic gastritis mucosal tissues, and normal mucosal tissues. The gene discussed is HPSE; the disease is chronic atrophic gastritis.