Essential genes play essential roles in CD8+ T cells infiltration in some cancers: CCL5, GBP5, GZMA, GZMH, IRF1, LAG3, NKG7, PRF1, and PSMB10 were identified as promoting factors for CD8+ T cell infiltration, all of which had independent prognostic effects. The gene discussed is GBP5; the disease is cancer.