found that T cell infiltration required tumor cell-derived CCL5, and CXCL9 secretion by IFN-γ differentiated myeloid cells was amplified; in immunoreactive and immune-responsive tumors, the synergistic effect of tumor-derived CCL5 and IFN-γ-induced CXCR3 ligand secreted by bone marrow cells is the key to coordinate T cell infiltration (39). The gene discussed is IFNG; the disease is neoplasm.