IFNA1 and systemic lupus erythematosus: SLE pathogenesis is complex, and emerging evidence show that defective immune complex and biological waste clearance, neutrophil extracellular trap production, nucleic acid sensing, lymphocyte signaling, and interferon (IFN) production pathways contribute to a loss of tolerance and tissue damage (3). Recent insights into lupus pathogenesis has led to the development of new targeted therapies with more favorable side effect profiles (4).