TNIP3 and systemic lupus erythematosus: The cytokine stimulus response-related down-regulated genes included GNAO1, COL3A1, IL6ST, SKIL, and LIFR. The inflammatory response-related up-regulated genes included TBXA2R, LYZ, AZU1, TNIP3, CCR7, UCN, and KLRG1. Inflammatory response is a biomarker and could lead to irreparable tissue damage of influenced organs in SLE progression (37, 38).