Rather than the Ki-67 labeling index, miR-106b–25 and its host gene MCM7, a member of the minichromosome maintenance complex (MCM) family of proteins, have been shown to be novel markers that correlate with tumor recurrence and progression in invasive ACTH-producing pituitary adenomas, including CCAs (68, 69). The gene discussed is POMC; the disease is pituitary gland adenoma.