Immunohistochemical analysis of SCA has demonstrated that lower expression of some proteins implicated in tumor progression and metastasis, such as galectin-3, a beta-galactoside-binding protein, and KLK10, belonging to the kallikrein family, in SCA than functioning ACTHomas may be one mechanism of its aggressiveness (30). Here, LGALS3 is linked to autosomal dominant cerebellar ataxia.