POMC and type 2 diabetes mellitus: The interaction between severity of emotional neglect and type 2 diabetes showed a significant, positive association with ACTH levels (est. = 0.05, p = 0.010) but no significant associations over time, implying a positive association of ACTH levels and severity of emotional neglect in patients with type 2 diabetes overall but no association of severity of emotional neglect and ACTH secretion in response to the TSST (Table 4 for more details on predictor estimates).