DiGeorge critical region 8 (DGCR8), implicated in miRNA synthesis is positioned in a region (22q11) where microdeletions have been linked with higher risk of schizophrenia. DGCR8 variants that change expression or function of genes may participate in the etiology of schizophrenia by affecting miRNA synthesis and modulation of gene expression. The gene discussed is DGCR8; the disease is schizophrenia.