Mechanistically, SIRT6 prevented hypertension by inducing the expression of GATA-binding protein 5 (GATA5) through inhibiting the expression of NK3 homeobox 2, a transcriptional repressor, by deacetylating histone H3 lysine 9 in its promoter (Guo et al., 2019). This evidence concerns the gene GATA5 and Hypertension.