The NLRP3 inflammasome, which comprises different domains, such as NLRP3, ASC, caspase-1, IL-1β, and IL-18, has been shown to have a crucial role in DKD (Ram et al., 2020), and to be related to renal inflammation and fibrosis (Alzahrani et al., 2020; An et al., 2020). The gene discussed is NLRP3; the disease is diabetic kidney disease.