Interleukin-6 (IL-6) exerts a pivotal role in regulating many cellular process and has been implicated in the pathogenesis of various inflammatory disorders such as COPD and IBD (Mudter and Neurath, 2007; Danese and Gao, 2010; Ruwanpura et al., 2011). The gene discussed is IL6; the disease is irritable bowel syndrome.