Among them are the IL-1 ligands, IL-1α and β, that act through IL-1 receptor, and implicated in NRLP3 inflammasome-induced cardiac inflammation, diabetic cardiomyopathy, septic shock, myocardial infarction, heart failure and atherosclerosis (Peiró et al., 2017; Abbate et al., 2020). This evidence concerns the gene IL1B and heart failure.