The upregulated genes associated with endometriosis in humans are related to cytokine–cytokine receptor interaction, phosphatidylinositol 3 kinase–Akt (PI3K–Akt) signaling pathway, pathway in cancer, MAPK signaling pathway, ECM–receptor interaction, Ras signaling pathway, toll-like receptor (TLR) signaling pathway, IL-17 signaling pathway, p53 signaling pathway, forkhead box protein O signaling pathway, focal adhesion, etc. Based on the above analyses, the rat model of endometriosis may be suitable for investigating the transcriptome level. This evidence concerns the gene AKT1 and cancer.