Naringin and its aglycone naringenin have shown anti-carcinogenic activities through cell signal transduction pathways in cancer (JAK–STAT pathway, PI3-kinase/Akt/mTOR pathway, Notch pathway, NF-κB and cox-2 pathway, Wnt pathway, MAPK-ERK pathway, TGF-β pathway) (Memariani et al., 2020). The gene discussed is MAPK1; the disease is cancer.