Magnesium chenoursodeoxycholic acid (Mg-CUD) suppression increases MMP-2 and tissue inhibitor of MMP-1 mRNA expression, as well as levels of NF-κB, TNF-α, IL-6, and COX-2 in carbon tetrachloride-induced liver fibrosis in rats (Kang et al., 2012). This evidence concerns the gene TNF and Hepatic fibrosis.