Others have shown protective effects of chymase inhibition in various cardiac conditions like myocardial ischemia-reperfusion injury, inflammation after acute myocardial ischemia/reperfusion, cardiac fibrosis, cardiac function after left ventricular repair, in cardiac function and survival after myocardial infarction, and in preventing cardiac fibrosis and improving diastolic dysfunction in the progression of heart failure (Jin et al., 2003; Matsumoto et al., 2003; Kanemitsu et al., 2008; Oyamada et al., 2011; Maeda et al., 2012; Hooshdaran et al., 2017). This evidence concerns the gene CMA1 and myocardial infarction.