Studies have shown that PARP-1 hyperactivation depletes NAD+, induces an accumulation of Poly (ADP-ribose) (PAR), and triggers mitochondrial damage in Alzheimer’s disease (AD) (Martire et al., 2015), Huntington’s disease (HD) (Cardinale et al., 2015), amyotrophic lateral sclerosis (ALS) (Kim et al., 2004), ischemic brains (Moroni, 2008), and PD (Yunjong et al., 2014). This evidence concerns the gene PARP1 and Parkinson disease.