MAPT and Alzheimer disease: The amyloid cascade hypothesis posits Aβ aggregates as a major culprit for the toxic effects on brain functions observed in AD, including neuro-inflammation, synaptic and neuronal loss, and tau-associated pathology, and has also been proposed to be responsible of the early cognitive decline observed in AD (Palop et al., 2007; Mucke and Selkoe, 2012; Verret et al., 2012; De Strooper and Karran, 2016; Frere and Slutsky, 2018).