APP and Alzheimer disease: In another commonly used AD mice model (APP/PS1), at 6 months old, it has been recently found in the CA1 region of the hippocampus that LTP magnitude is significantly reduced if the recorded CA1 pyramidal neuron is located in the vicinity of Aβ plaques (<200 μm), when using a STDP-induction protocol (t-LTP) (Garad et al., 2021).