ACO2 and Alzheimer disease: For instance, many OXPHOS-related proteins, such as Nduf subunits, Aco2, and mt-Co proteins and several metabolic proteins such as Gpd2, Cs, Gpi, Pkm, Wdr1, Sdha, Ddx1, and Aldh1l1 demonstrated altered levels and were previously identified in AD, HD, and SCA1 (Sorolla et al., 2008; Sánchez et al., 2016; Lunnon et al., 2017).