ATXN3 and Anxiety: Moreover, the most advanced disease stage marked by highly reduced body weight, anxiety, and severe motor symptoms in 18-month-old animals is also characterized by the excessive size of Atxn3 inclusions and were observed both in the nuclei and axons, whereas in pre-symptomatic 2-month old SCA3 mice ataxin-3-positive aggregates were relatively smaller and detected only in cell nuclei (Wiatr et al., 2019).