Downregulation of Cryab, which was one of the most frequently identified proteins implicated in the pathology of neurodegenerative disease (Zhu and Reiser, 2018), was confirmed with vacuum dot blot assay (p < 0.05; two-sample t-test) in the cerebral cortex (10, 14, and 18-month-old; Supplementary Figure 4A) and cerebellum (18-month-old; Supplementary Figure 4B). The gene discussed is CRYAB; the disease is neurodegenerative disease.