SNCA and Parkinson disease: The neuropathology of PD is defined by intraneuronal accumulation of alpha-synuclein amyloids, namely Lewy bodies and Lewy neurites, low grade neuroinflammation and selective neuronal dysfunction with subsequent neurodegeneration, involving mainly the aminergic neurocircuits (Braak et al., 2003a; Balestrino and Schapira, 2020).