Pioglitazone inhibited tau phosphorylation (Cho et al., 2013; Hamano et al., 2016; Moosecker et al., 2019) and oligomerization (Hamano et al., 2016) in cell-based tauopathy models, and in pre-clinical mouse models (Escribano et al., 2010; Searcy et al., 2012). This evidence concerns the gene MAPT and tauopathy.