Improved memory retention. Decreased amyloid plaque deposits, reduced soluble and insoluble Aβ40 and Aβ42 in 6-month-old mice; reduced insoluble Aβ42 and Aβ40 and soluble Aβ40 in 12-month-old mice; reduced reactive microglia and astrocytes and enhanced microglial phagocytosis; increased IL-1β, TNFα, Tm1, Fizz1, Arg1 expression;. The gene discussed is RETNLB; the disease is amyloidosis.