Multiple SNPs in TOMM40 are associated with AD risk independently of the APOE gene., including rs7259620 (Takei et al., 2009; Nazarian et al., 2019), rs760136 (Marioni et al., 2018), rs2075650 (He et al., 2016; Huang et al., 2016; Bussies et al., 2020; Soyal et al., 2020; Squillario et al., 2020), and rs10524523 (Roses, 2010; Li et al., 2013; Yu et al., 2017a, b). The gene discussed is APOE; the disease is Alzheimer disease.