The characteristic pathological changes in AD include senile plaques, neuron fiber tangles, and extensive neuronal loss, while the pathogenesis is not completely clear (Attems and Jellinger, 2014), involving the Aβ cascade hypothesis, the tau protein abnormal modification hypothesis, the cholinergic injury hypothesis, the cholinergic injury hypothesis, etc. (Hardy and Allsop, 1991; Strittmatter et al., 1993; Schorderet, 1995). This evidence concerns the gene MAPT and Alzheimer disease.