TGFB1 and Familial prostate cancer: It impeded LPS-dependent EMT in prostate cancer cell lines (PC-3 and LNCaP) through blocking of the Hh signaling pathway [102] and impeded the EMT process in colorectal cancer cells through overexpression of E-cadherin and suppression of vimentin by blocking the TGFβ1/Smads signaling pathway [103].