HPSE and neoplasm: The expressions of heparanase in 4T1 and B16F10 cells were significantly reduced in tumor cells after infection with Salmonella (MOI=200) (Fig. 1C and D) (p<0.05 for S.C. MOI=0 versus MOI=200 in 4T1; p<0.01 for S.C. MOI=0 versus MOI=200 in B16F10).